Why Can Parents with Normal Chromosomes Have Children with Abnormal Chromosomes?

2024-09-28 20:55:00，浏览量： 30次

 

Mrs. Wang, over the past two years, had several hopeful pregnancies, but each time, she suffered miscarriages due to chromosomal abnormalities in the fetus. Her experience is not uncommon. In fact, many couples face the confusion: why do we both have normal chromosomes, but the embryos still develop chromosomal abnormalities?

 

Chromosomal abnormalities refer to deviations in the number or structure of chromosomes, such as deletions, duplications, or translocations. This can occur during the early stages of embryonic development, even if the parents have perfectly normal chromosomes. In natural conception, chromosomal abnormalities are one of the leading causes of miscarriage, especially for older women, who face a higher risk. As women age, the quality of their eggs declines, increasing the likelihood of chromosomal mis-segregation, leading to abnormalities.

 

Mrs. Wang, however, is not of advanced age, and both she and her husband are in good health. This left her puzzled as to why their embryos repeatedly showed chromosomal issues. In reality, even when the parents’ chromosomes are normal, many factors can affect the union of sperm and egg during embryo formation, such as exposure to environmental radiation, chemical agents, or even daily life stress. All of these factors can result in accidental chromosomal errors during embryo replication or division.

 

According to Dr. Nathan Zhang from IVF USA, age is a significant factor affecting chromosomal abnormalities in embryos. As a woman ages, her ovarian function gradually declines, and the likelihood of chromosomal errors during egg division increases. A man’s age also impacts sperm quality, particularly the integrity of DNA in sperm. Therefore, even though couples may not show signs of chromosomal abnormalities during routine health checks, chromosomal abnormalities can still occur in their embryos.

 

To assist patients like Mrs. Wang, IVF USA utilizes advanced IVF-PGT technology. The core of this technology lies in performing genetic diagnostics or screening (PGD/PGS) on the embryos before transfer, allowing for the selection of embryos with normal chromosomes for implantation. This approach not only greatly enhances the chances of a successful pregnancy but also effectively reduces the risk of miscarriage due to chromosomal abnormalities.

 

Dr. Nathan Zhang explains that IVF-PGT is particularly suited for women with a history of chromosomal abnormalities, recurrent miscarriages, or older age. With this technology, doctors can precisely select the healthiest embryos, giving patients a higher chance of a successful pregnancy and the birth of a healthy baby.

 

Every patient’s situation is unique. IVF USA provides personalized treatment plans through comprehensive medical evaluations. By analyzing various indicators such as ovarian function, hormone levels, and uterine condition, the team at IVF USA can design the most suitable IVF-PGT protocol for each patient. This personalized approach not only increases the chances of success but also minimizes unnecessary risks.

IVF USA not only offers egg freezing and IVF services in the U.S. but has also actively expanded its global reproductive service network. Currently, IVF USA provides egg freezing and IVF services in the U.S. and has extended its operations to other regions such as Japan, Thailand, Mexico, Taiwan, and Hong Kong, working closely with leading IVF doctors worldwide. We provide thorough, scientific assessments and support to help you achieve reproductive success. Through the guidance of Dr. Nathan Zhang and his team, many families have already realized their dreams of parenthood. If you are facing similar challenges, IVF USA will be your strongest support, helping you welcome a healthy baby into your life.